This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
KRAS Gene Ontology
The KRAS Gene ontology terms were discovered by AmiGO, a search engine in The Gene Ontology[1] website. The Gene Ontology project is a bioinformatics project which aims to unify the representation of the gene and gene products accross all species and databases.
Biological Process
- activation of MAPKK activity
- axon guidance
- blood coagulation
- cytokine-mediated signaling pathway
- epidermal growth factor receptor signaling pathway
- cytokine-mediated signaling pathway
- insulin receptor signaling pathway
- leukocyte migration
- MAPKKK cascade
- nerve growth factor receptor signaling pathway
- positive regulation of MAP kinase activity
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of nitric-oxide synthase activity
- Ras protein signal transduction
- response to glucocorticoid stimulus
- response to mineralocorticoid stimulus
- signal transduction
- social behavior
- intracellular
- membrane raft
- mitochondrion
- plasma membrane
- GDP binding
- GMP binding
- GTP binding
- GTPase activity
- LRR domain binding
- nucleotide binding
- protein binding
Analysis
JMML is a form of chronic leukemia. KRAS is important in the regulation of hematopoetic cells, with roles in growth,
survival, differentiation, cytokine production,
chemotaxis, vesicle-trafficking, and phagocytosis[2]. Given the complexity of the pathways associated with KRAS as shown above, it is no surprise that a mutation in it can lead to errors in hematopoetic stem cell differentiation and thus leukemia.
References
1) The Gene Ontology
http://www.geneontology.org/
2) Pfam
http://pfam.sanger.ac.uk/
http://www.geneontology.org/
2) Pfam
http://pfam.sanger.ac.uk/