This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.

KRAS Gene Ontology

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The KRAS Gene ontology terms were discovered by AmiGO, a search engine in The Gene Ontology[1] website. The Gene Ontology project is a bioinformatics project which aims to unify the representation of the gene and gene products accross all species and databases.
Biological Process
  • activation of MAPKK activity
  • axon guidance
  • blood coagulation
  • cytokine-mediated signaling pathway
  • epidermal growth factor receptor signaling pathway
  • cytokine-mediated signaling pathway 
  • insulin receptor signaling pathway 
  • leukocyte migration
  • MAPKKK cascade
  • nerve growth factor receptor signaling pathway
  • positive regulation of MAP kinase activity
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of nitric-oxide synthase activity 
  • Ras protein signal transduction
  • response to glucocorticoid stimulus
  • response to mineralocorticoid stimulus
  • signal transduction
  • social behavior
Cellular Component
  • intracellular
  • membrane raft
  • mitochondrion
  • plasma membrane
Molecular Function
  • GDP binding
  • GMP binding
  • GTP binding
  • GTPase activity
  • LRR domain binding
  • nucleotide binding
  • protein binding

Analysis

JMML is a form of chronic leukemia. KRAS is important in the regulation of hematopoetic cells, with roles in growth, survival, differentiation, cytokine production, chemotaxis, vesicle-trafficking, and phagocytosis[2]. Given the complexity of the pathways associated with KRAS as shown above, it is no surprise that a mutation in it can lead to errors in hematopoetic stem cell differentiation and thus leukemia.

References

1) The Gene Ontology
http://www.geneontology.org/
2) Pfam
http://pfam.sanger.ac.uk/